Cardiff is the first Trinity Mirror centre to adopt the model - an editorial structure supporting a digital-first publishing process - since its recent launch in Newcastle.
Alan Edmunds, Media Wales Editor-in-Chief, announced several new key appointments as part of the change.
He said: "This move is a great opportunity for all of our journalists to enhance their skills and grow our audience even further as we continue to see WalesOnline's traffic increase at a rapid pace.
"The model sets us up brilliantly to deliver outstanding and engaging content for our readers and advertisers across all digital and print platforms."
Taking on some of the new key roles are current WalesOnline Editor Ceri Gould, who will also now deputise for the Editor-in-Chief.
Catrin Pascoe becomes Editor of the Daily Content pillar and the South Wales Echo.
Paul Rowland, whose secondment to the Newsroom 3.1 launch project in Newcastle ends this week, becomes Editor, Digital Development and Audience Engagement.
Hannah Jones takes on the role of Editor, Agenda/Ents/TV.
Wayne Davies heads up newspaper production as Print Publishing Editor, alongside Sandra Loy who becomes the new Editor of Wales On Sunday.
These roles, and others throughout the newsroom, closely mirror those in Newcastle.
Edmunds said staff presentations and discussions will be held by the editors with all staff in the next fortnight.
